MCM8- AND MCM9 DEFICIENCIES CAUSE LIFELONG INCREASED HEMATOPOIETIC DNA DAMAGE DRIVING P53-DEPENDENT MYELOID TUMORS

MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors

Summary: Hematopoiesis is particularly sensitive to DNA damage.Myeloid tumor incidence increases in patients with DNA repair defects and after chemotherapy.It is not known why hematopoietic cells are highly vulnerable to DNA damage.Addressing this question is complicated by the paucity of mouse models of hematopoietic malignancies due to defective

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Improving Air Pollutant Metal Oxide Sensor Quantification Practices through: An Exploration of Sensor Signal Normalization, Multi-Sensor and Universal Calibration Model Generation, and Physical Factors Such as Co-Location Duration and Sensor Age

As EnlargementGear low-cost sensors have become ubiquitous in air quality measurements, there is a need for more efficient calibration and quantification practices.Here, we deploy stationary low-cost monitors in Colorado and Southern California near oil and gas facilities, focusing our analysis on methane and ozone concentration measurement using m

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